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Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy (PBMC)

ABSTRACT: The Gauging Response in Allergic Rhinitis to Sublingual and Subcutaneous Immunotherapy (GRASS) study was a randomized, double-blind, placebo-controlled trial of individuals with timothy grass allergy who received 2 years of placebo, subcutaneous (SCIT), or sublingual immunotherapy (SLIT) and were followed for a total of 3 years. Here we utilized longitudinal transcriptomic profiling of nasal brush and peripheral blood mononuclear cell (PBMC) samples after allergen provocation collected in the GRASS study to uncover airway and systemic expression pathways mediating responsiveness to immunotherapy.

ORGANISM(S): Homo sapiens

PROVIDER: GSE206151 | GEO | 2023/12/31

REPOSITORIES: GEO

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Nasal and blood transcriptomic pathways underpinning the clinical response to grass pollen immunotherapy (nasal)

Project description:The Gauging Response in Allergic Rhinitis to Sublingual and Subcutaneous Immunotherapy (GRASS) study was a randomized, double-blind, placebo-controlled trial of individuals with timothy grass allergy who received 2 years of placebo, subcutaneous (SCIT), or sublingual immunotherapy (SLIT) and were followed for a total of 3 years. Here we utilized longitudinal transcriptomic profiling of nasal brush and peripheral blood mononuclear cell (PBMC) samples after allergen provocation collected in the GRASS study to uncover airway and systemic expression pathways mediating responsiveness to immunotherapy.

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Expression data from patients that has received grass pollen sublingual immunotherapy treatment for two years.

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Expression data from patients that has received grass pollen sublingual immunotherapy treatment for two years.

Project description:Expression data from patients that has received grass pollen sublingual immunotherapy treatment for two years.

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Effect of Intradermal Immunotherapy (IDIT) injections on gene expression profiles of activated T cells derived from skin biopsy explants

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