Transcriptomics

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KYSE170 transfected with ncRNA or miR-210


ABSTRACT: MicroRNAs are small non-coding RNA species, some of which are playing important roles in malignancies. However, roles of miR-210 in cancer have yet to be unknown and controversial. Here, we found the expression level of miR-210 is downregulated in human esophageal squamous cell carcinoma and its cell lines. Additionally, we demonstrate that miR-210 inhibits cancer cell survival and proliferation through upregulation of cell death and induction of cell cycle arrest at G1/G0 and G2/M phases. However, candidate target mRNAs of miR-210 and the mechanism behind observed phenomena is uncertain. Then, we performed comprehensive gene expression analysis to identify candidate target mRNAs and understand their mechanisms.

ORGANISM(S): Homo sapiens

PROVIDER: GSE20637 | GEO | 2011/01/05

SECONDARY ACCESSION(S): PRJNA124857

REPOSITORIES: GEO

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