Transcriptomics

Dataset Information

0

Effects of RGMc on BMP2 and BMP6-mediated Gene Expression in Hep3B Liver Cells


ABSTRACT: Mutations in repulsive guidance molecule c (RGMc) / hemojuvelin (HJV) cause juvenile hemochromatosis, an aggravated iron overload disorder that presents early in life. Patients with juvenile hemochromatosis, and RGMc knockout mice, have diminished expression of the key iron-regulatory peptide, hepcidin. This suggests that RGMc plays a critical role in the regulation of iron homeostasis; however the mechanisms of RGMc actions are unknown. Recent studies have shown that RGMc directly binds to the growth factors, bone morphogenetic protein 2 and 6 (BMP2 and BMP6), and it is possible that this interaction regulates aspects of iron metabolism. We used microarrays to examine the effects of RGMc on BMP2- and BMP6-mediated gene expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE20671 | GEO | 2010/06/15

SECONDARY ACCESSION(S): PRJNA124929

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2010-06-23 | E-GEOD-20671 | biostudies-arrayexpress
2017-01-31 | GSE90506 | GEO
2023-12-28 | PXD039830 | Pride
2008-07-07 | GSE10421 | GEO
2022-12-21 | GSE215324 | GEO
2024-01-25 | GSE235975 | GEO
2024-01-25 | GSE235692 | GEO
2023-05-03 | GSE186655 | GEO
2015-08-13 | E-GEOD-40069 | biostudies-arrayexpress
2023-12-25 | GSE223871 | GEO