Identification of novel sub-microscopic copy number aberrations in adult acute myeloid leukemia
Ontology highlight
ABSTRACT: In this study we have screened 56 pairs of AML samples for cryptic copy number aberration and loss-of-heterozygosity. We have identified 80 CNAs among 56 patient samples; 21 containing <5 genes while 11 contained or were present within a single gene. Four (7%) patients carried gains at sub-telomeres on multiple chromosomes. Some of the cryptic regions are common with other recent studies while most are novel. Also, we show that it is better to analyse sample at diagnosis and sample at remission (paired control) both against a common unrelated control and then compare the two results than analysing the diagnostic sample directly against the paired control.
ORGANISM(S): Homo sapiens
PROVIDER: GSE20672 | GEO | 2012/03/08
SECONDARY ACCESSION(S): PRJNA124931
REPOSITORIES: GEO
ACCESS DATA