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Transcriptional profiling of Bmal1WT and Bmal1KO Tregs

ABSTRACT: We isolated visceral adipose tissue (VAT) Tregs from Foxp3.YFP-Cre Bmal1WT or Foxp3.YFP-Cre bmal1flox mice fed a normal lean diet or a high-fat diet. VAT Tregs were also sorted after adoptive transfer. We found that Bmal1KO Tregs are more activated in lean mice, after 4 weeks HFD and after adoptive transfer, but loseVAT Treg signature after 16 weeks of high-fat diet feeding.

ORGANISM(S): Mus musculus

PROVIDER: GSE206775 | GEO | 2022/07/28

REPOSITORIES: GEO

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Transcriptional profiling of visceral adipose tissue from Foxp3.YFP-Cre Bmal1WT and Foxp3.YFP-Cre Bmal1KO mice after 16 weeks of high-fat diet

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