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Ablation of ER stress-linked kinase PERK in cancer cells elicits protective T cell immunity by paraptosis immunogenic cell death-induced Type-I IFN

ABSTRACT: C57BL6 wildtype mice were injected with B16F10 melanoma transduced with either untargeted sgRNA (Scramble) or PERK (EIF2AK3) knockout (KO) sgRNA. At day 17, tumors were harvested to isolate cKit+ (CD117) precursors via magnetic bead enrichment. These cKit expressing precursors were then sequenced.

ORGANISM(S): Mus musculus

PROVIDER: GSE206783 | GEO | 2022/07/28

REPOSITORIES: GEO

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AMPK activation enhances apoptotic priming and BCL2 dependence via PERK phosphorylation

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ISR target genes revealed by comprehensive microarray network study using Perk -/-, Atf4 -/-, eIF2a S51A mutant, Fv2E-PERK

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2015-09-01 | E-GEOD-49598 | biostudies-arrayexpress

ISR pathway activation signatures in MEFs: GCN2 and PERK

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2015-08-05 | E-GEOD-49645 | biostudies-arrayexpress

PERK is a critical metabolic hub for immunosuppressive function in macrophages

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2020-05-27 | PXD018253 | Pride

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