Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Single-cell ATAC profiles of the somites and myotomes at embryonic stages E18, E21, and E28 from Tibetan pigs (ZZ) and Duroc x Tibetan pigs (DZ)

ABSTRACT: To investigate the upstream regulatory networks in myogenesis that lead to the establishment of the myogenic lineage and subsequent differentiation, we proformed scATAC-seq of pig somite and myotome cells from Tibetan pigs (ZZ) and Duroc×Tibetan pigs (DZ) at several embryonic stages (E18, E21, and E28).

ORGANISM(S): Sus scrofa

PROVIDER: GSE206913 | GEO | 2023/01/15

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Single-cell RNA gene expression profiles of the somites and myotomes at embryonic stages E18, E21, and E28 from Tibetan pigs (ZZ) and Duroc x Tibetan pigs (DZ)

Project description:To investigate the upstream regulatory networks in myogenesis that lead to the establishment of the myogenic lineage and subsequent differentiation, we proformed scRNA-seq of pig somite and myotome cells from Tibetan pigs (ZZ) and Duroc×Tibetan pigs (DZ) at several embryonic stages (E16, E18, E21, and E28).

2023-01-15 | GSE206911 | GEO

Somites and myotomes at embryonic stages E18, E21, and E28 from Tibetan pigs (ZZ) and Duroc x Tibetan pigs (DZ)

Project description:Somites and myotomes at embryonic stages E18, E21, and E28 from Tibetan pigs (ZZ) and Duroc x Tibetan pigs (DZ)

| PRJNA852597 | ENA

Single-cell ATAC profiles of the somites and myotomes at embryonic stages E18, E21, and E28 from Tibetan pigs (ZZ) and Duroc x Tibetan pigs (DZ)

Project description:Single-cell ATAC profiles of the somites and myotomes at embryonic stages E18, E21, and E28 from Tibetan pigs (ZZ) and Duroc x Tibetan pigs (DZ)

| PRJNA852595 | ENA

Somites and myotomes at embryonic stages E18, E21, and E28 from Tibetan pigs (ZZ) and Duroc x Tibetan pigs (DZ)

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-01-14 | GSE206914 | GEO

Single-cell RNA gene expression profiles of the somites and myotomes at embryonic stages E18, E21, and E28 from Tibetan pigs (ZZ) and Duroc x Tibetan pigs (DZ)

Project description:Single-cell RNA gene expression profiles of the somites and myotomes at embryonic stages E18, E21, and E28 from Tibetan pigs (ZZ) and Duroc x Tibetan pigs (DZ)

| PRJNA852593 | ENA

Gene Co-Expression Network Analysis Unraveling Transcriptional Regulation of High-altitude Adaptation of Tibetan Pigs

Project description:To elucidate further molecular mechanisms underlying the regulation of hypoxia-adaptive phenotypes in Tibetan pigs, we used transcriptome microarrays from lung tissues of Tibetan pigs and Duroc pigs both at high and low altitude analyzed differentially expressed genes (DEGs), biological pathway and constructed co-expression regulation network. A total of 3,068 DEGs were identified which involved metabolic process, cellular process, immune biological process and angiogenesis pathway. The regulatory (RIF) and phenotypic (PIF) impact factors analysis identified several known and potentially regulators of hypoxia adaption, including IKBKG, KLF6 and RBPJ (RIF1), SF3B1, EFEMP1, HOXB6 and ATF6 (RIF2).

2016-07-15 | GSE84409 | GEO

Genome-wide profiling of gene expression and DNA methylation provides insight into low-altitude acclimation in Tibetan pigs [RNA-seq]

Project description:To explore the exceptional mechanisms of gene expression and DNA methylation that are induced by low altitude environments in Tibetan pigs, we performed a comparative transcriptomic analysis of skeletal muscle in indigenous Tibetan pigs that reside in high altitude regions (～4,000 m) and their counterparts that migrated to the geographically neighboring low-altitude regions (～500 m) for nearly ten generations. We identified protein coding genes that related to hypoxia response (EGLN3 and FLT1), oxygen transport and energy metabolism (TFB2M), and two long non-coding RNAs (TCONS_00039686 and TCONS_00084992) that associated with the regulation of transcription and various nucleolus and organelle lumen, were differentially expressed between Tibetan pigs and their counterparts in low-altitude regions, thus might be the potential candidate regulators in skeletal muscle of low-altitude acclimation in Tibetan pigs. We also found genes embedded in differentially methylated regions between Tibetan pigs and their counterparts in low-altitude regions were mainly involved in ‘Starch and sucrose metabolism’, ‘glucuronosyltransferase activity’ processes, hypoxia and energy metabolism. We envision that this study will serve as a valuable resource for mammal acclimatization research and agricultural food industry.

2017-11-25 | GSE90511 | GEO

Genome-wide profiling of gene expression and DNA methylation provides insight into low-altitude acclimation in Tibetan pigs [DNA methylation]

2017-11-25 | GSE90510 | GEO

A comparison of genome-wide DNA methylation profiles between Tibetan and Yorkshire pigs

Project description:We investigated the heart tissue whole-genome DNA methylation data of Tibetan and Yorkshire pigs raised at high and low altitudes using MeDIP-seq (methylated DNA immunoprecipitation sequencing) technologies, in order to comparatively analyze epigenetic regulation in the two breeds under normoxic and hypoxic conditions. In addition, we aimed to identify the key genes and molecular mechanisms that are involved in adaptation to high altitude in the Tibetan pig. The results of bisulphite sequencing and RT-qPCR indicated that the differentially methylated genes identified in MeDIP-seq were credible. Our results provide new insights into the molecular mechanisms and the epigenetic mechanism involved in hypoxic adaptation in pigs, and a greater understanding of human hypoxic diseases.

2018-05-23 | GSE114779 | GEO

Feces of Tibetan pigs

Project description:Feces of Tibetan pigs Raw sequence reads

| PRJNA451381 | ENA