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Pharmacological inhibition of the MAPK pathway ameliorates RIT1M90I-driven cardiac tissue hypertrophy.

ABSTRACT: To investigate whether MEK1/2 inhibition attenuates MAPK signaling in RIT1 M90I mice and ameliorates cardiac tissue overgrowth, we treated a cohort of 4-week-old mice harboring a germline Rit1M90I variant with the allosteric MEK1/2 inhibitor trametinib (MEKi).

ORGANISM(S): Mus musculus

PROVIDER: GSE207187 | GEO | 2022/12/01

REPOSITORIES: GEO

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