Transcriptomics

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Glycosylated clusterin species facilitate amyloid beta toxicity in human neurons.


ABSTRACT: Clusterin (CLU) is one of the most significant genetic risk factors for late onset Alzheimer’s disease. Numerous studies have now demonstrated that CLU-AD mutations and amyloid-β (Aβ) treatment alter the trafficking and localisation of glycosylated CLU. iPSCs with altered CLU trafficking were generated following the removal of CLU exon 2 by CRISPR/Cas9 gene editing. Neurons were generated from control, unedited and exon 2 -/- iPSCs and were incubated with aggregated Aβ peptides. Changes in cell death and neurite length were quantified to determine if altered CLU protein trafficking influenced neuronal sensitivity to Aβ.

ORGANISM(S): Homo sapiens

PROVIDER: GSE207466 | GEO | 2022/07/05

REPOSITORIES: GEO

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