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Gene expression analysis of the hippocampus in Il18+/+ and Il18-/- with restraint stress

ABSTRACT: Interleukin-18 (IL-18) was one of the inflammatory cytokines and related to major depressive disorder (MDD) and dementia. We previously investigated IL-18 knockout (Il18−/−) mice developed impaired learning and memory, more anxiety, and less motivation comparing to Il18+/+ mice. In the Il18−/− mice with acute stress, both the immobility time in the forced swim test and the tail suspension test were decreased, even though no difference was observed in the Il18+/+ mice. To reveal the mechanism, RNA-Seq was performed.

ORGANISM(S): Mus musculus

PROVIDER: GSE207669 | GEO | 2022/10/21

REPOSITORIES: GEO

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Gene expression analysis of the hippocampus in Il18+/+ and Il18-/- mice at 12 weeks of age

Project description:Interleukin-18 (IL-18) was one of the inflammatory cytokines and related to major depressive disorder (MDD) and dementia. Compared with Il18+/+ mice, IL-18 knockout (Il18−/−) mice developed impaired learning and memory, more anxiety, and less motivation. To reveal the mechanism, the microarray was performed.

2019-12-31 | GSE108485 | GEO

Gene expression analysis of the hippocampus in Il18+/+ and Il18-/- with restraint stress

Project description:Gene expression analysis of the hippocampus in Il18+/+ and Il18-/- with restraint stress

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IL-18 mediates sickle cell cardiomyopathy and inducible ventricular arrhythmias

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Gene expression analysis of the hippocampus in Il18+/+ and Il18-/- mice at 12 weeks of age

Project description:Gene expression analysis of the hippocampus in Il18+/+ and Il18-/- mice at 12 weeks of age

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Interleukin-18 and cytotoxic impairment are independent and synergistic causes virus-induced hyperinflammation in mice

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IL-18 nAbs block deleterious inflammatory cytokines induced by acute β-AR stimulation in heart

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IL18 signaling controls the CCR6-CCL20-dependent migration axis used by IL18R+ Tregs to enter the thymus

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A fusion protein complex that combines IL12, IL15, and IL18 signaling to induce memory-like NK cells for cancer immunotherapy

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