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Claudin-4–adhesion signaling drives breast cancer metabolism and progression via liver X receptor β

ABSTRACT: Cell adhesion molecules exhibit the signaling abilities to control a variety of physiological and pathological processes; however, the underlying molecular basis remains poorly defined. Here, we demonstrate that the claudin-4 (CLDN4)-adhesion signaling accelerates breast cancer metabolism and progression via the nuclear receptor LXRb (liver X receptor b). Knockout and rescue experiments revealed that the CLDN4 signaling targets S432 in LXRb, leading to enhanced cell proliferation and tumor growth in breast cancer cells. In addition, RT-qPCR analysis showed the CLDN4-regulated genes are classified into at least six groups by distinct LXRb- and LXRbS432-dependence. Collectively, our results provide a link between cell adhesion and nuclear receptor signalings to coordinate cancer metabolism and advancement.

ORGANISM(S): Homo sapiens

PROVIDER: GSE207704 | GEO | 2023/04/19

REPOSITORIES: GEO

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