Transcriptomics

Dataset Information

0

Tcte1 knockout influence on energy chain transportation, apoptosis and spermatogenesis – implications for male infertility


ABSTRACT: RNA sequencing (RNAseq) in testis tissue has been done to obtain an answer about the influence of Tcte1 null mutation in knockout mice on the expression pattern of other gonadal genes in male animals that may be influential for male fertility status. Homozygous males (infertile) revealed oligoasthenoteratozoospermia (incl. circular pathway of sperm motility), while heterozygous animals (fertile) manifested oligozoospermia, suggesting haploinsufficiency. RNA-sequencing of the mutant testicular tissue showed the influence of Tcte1 mutations on the expression pattern of genes responsible for mitochondrial ATP processing, linked with apoptosis, or spermatogenesis.

ORGANISM(S): Mus musculus

PROVIDER: GSE207805 | GEO | 2023/02/01

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-05-23 | PXD046848 | Pride
2011-03-17 | E-GEOD-27965 | biostudies-arrayexpress
2023-04-11 | PXD037531 | Pride
2021-09-20 | GSE160969 | GEO
2024-02-28 | PXD040292 | Pride
2016-06-28 | GSE78131 | GEO
2016-06-28 | E-GEOD-78131 | biostudies-arrayexpress
2019-11-11 | GSE135825 | GEO
2019-08-01 | GSE134802 | GEO
2010-11-19 | GSE18610 | GEO