Genomics

Dataset Information

0

Chromatin reorganization drives expression of functional maturation genes in senescent pancreatic beta cells (Series2 - chromatin sccessibility, ATAC-seq)


ABSTRACT: Using a unique model of cultured human beta cell senescence we show that chromatin reorganization leads to activation of enhancers regulating functional maturation genes, concomitantly with acquisition of glucose-stimulated insulin secretion capacity. Interferon-response genes are elevated in senescent beta cells, but cytokine-encoding senescence-associated secretory phenotype (SASP) genes are not. Human beta cell senescence thus involves chromatin-driven upregulation of a functional maturation program and of interferon-stimulated genes, changes that could increase both insulin secretion and immune reactivity.

ORGANISM(S): Homo sapiens

PROVIDER: GSE207818 | GEO | 2024/06/26

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2024-06-26 | GSE207825 | GEO
2024-06-26 | GSE207822 | GEO
2024-06-26 | GSE207816 | GEO
2019-08-19 | GSE135944 | GEO
2020-05-01 | GSE130651 | GEO
2016-06-02 | GSE68853 | GEO
2024-01-18 | MODEL2401110001 | BioModels
2022-05-16 | GSE191194 | GEO
2023-12-01 | GSE248349 | GEO
2016-11-26 | GSE90531 | GEO