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FBP1 acts as a protein phosphatase to dephosphorylate histone H3

ABSTRACT: We report nuclear FBP1 interacts with PPARa and binds to the promoter regions of PPARa-mediated b-oxidation genes. S170-phosphorylated FBP1 with an altered catalytic domain structure functions as a protein phosphatase that dephosphorylates histone H3 at T11 and suppresses PPARa-mediated gene expression. Chromatin immunoprecipitation DNA-sequencing (ChIP-seq) for FBP1 and PPARa with glucose deprivation in L02 cells.

ORGANISM(S): Homo sapiens

PROVIDER: GSE207844 | GEO | 2022/10/04

REPOSITORIES: GEO

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