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Intrinsically determined turnover underlies broad heterogeneity in plasma-cell lifespan

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE207980 | GEO | 2023/05/09

REPOSITORIES: GEO

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Intrinsically determined turnover underlies broad heterogeneity in plasma-cell lifespan

Project description:Antibody persistence frequently determines the longevity of immunity, yet the mechanisms that set antibody-producing plasma cell turnover rates are unestablished. While it is proposed that new plasma cells displace existing ones in competition for specialised survival niches, it is also possible that the spontaneous loss of existing plasma cells frees niches thereby creating opportunities for recruitment, possibilities with quite different implications for maximising antibody production and persistence. Here, using a genetic reporter to timestamp plasma cells, we define the distribution, phenotype, transcriptional program and population structure of long-lived plasma cells and calculate turnover dynamics. We show that the attributes of longevity are acquired and that turnover of long-lived plasma cells at homeostasis is unaffected by the absence of B cells, indicating that the mechanism of turnover is independent of competition. We propose that understanding plasma cell population dynamics may allow their manipulation to achieve specific outcomes.

2023-05-09 | GSE207979 | GEO

Intrinsically determined turnover underlies broad heterogeneity in plasma-cell lifespan

2023-05-09 | GSE196924 | GEO

Intrinsically determined turnover underlies broad heterogeneity in plasma-cell lifespan

Project description:Intrinsically determined turnover underlies broad heterogeneity in plasma-cell lifespan

| PRJNA857893 | ENA

Intrinsically determined turnover underlies broad heterogeneity in plasma-cell lifespan

Project description:Intrinsically determined turnover underlies broad heterogeneity in plasma-cell lifespan

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Intrinsically determined turnover underlies broad heterogeneity in plasma-cell lifespan

Project description:Intrinsically determined turnover underlies broad heterogeneity in plasma-cell lifespan

| PRJNA807721 | ENA

Polycomb Underlies Transcriptional Heterogeneity in Lineage Priming of Embryonic Stem Cells

Project description:This SuperSeries is composed of the SubSeries listed below.

2016-10-11 | GSE65289 | GEO

Metabolic heterogeneity underlies reciprocal fates of TH17 cell stemness and plasticity

Project description:This SuperSeries is composed of the SubSeries listed below.

2018-12-27 | GSE121599 | GEO

Critical role of histone turnover in neuronal transcription and plasticity

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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PGC-1β Promotes Enterocyte Lifespan and Tumorigenesis in the Intestine

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

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Intrinsically determined cell death of developing cortical interneurons.

Project description:Cortical inhibitory circuits are formed by ?-aminobutyric acid (GABA)-secreting interneurons, a cell population that originates far from the cerebral cortex in the embryonic ventral forebrain. Given their distant developmental origins, it is intriguing how the number of cortical interneurons is ultimately determined. One possibility, suggested by the neurotrophic hypothesis, is that cortical interneurons are overproduced, and then after their migration into cortex the excess interneurons are eliminated through a competition for extrinsically derived trophic signals. Here we characterize the developmental cell death of mouse cortical interneurons in vivo, in vitro and after transplantation. We found that 40% of developing cortical interneurons were eliminated through Bax (Bcl-2-associated X)-dependent apoptosis during postnatal life. When cultured in vitro or transplanted into the cortex, interneuron precursors died at a cellular age similar to that at which endogenous interneurons died during normal development. Over transplant sizes that varied 200-fold, a constant fraction of the transplanted population underwent cell death. The death of transplanted neurons was not affected by the cell-autonomous disruption of TrkB (tropomyosin kinase receptor B), the main neurotrophin receptor expressed by neurons of the central nervous system. Transplantation expanded the cortical interneuron population by up to 35%, but the frequency of inhibitory synaptic events did not scale with the number of transplanted interneurons. Taken together, our findings indicate that interneuron cell death is determined intrinsically, either cell-autonomously or through a population-autonomous competition for survival signals derived from other interneurons.

| S-EPMC3726009 | biostudies-literature

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