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The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE208072 | GEO | 2023/05/05

REPOSITORIES: GEO

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The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates [RNA-Seq]

Project description:When stem cells activate a member of the SOX family of pioneer factors, they bind their cognate sequences within condensed chromatin, not only evicting the associated nucleosome, but also recruiting H3K4-monomethylases, which modify flanking nucleosomes to open chromatin and activate one lineage program; simultaneously, pioneer factors also silence alternative fates, but in this case act indirectly, through competing for H3K4-monomethylases pre-existing at the original fate genes.

2023-05-05 | GSE208071 | GEO

The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates [CUT&RUN]

2023-05-05 | GSE208070 | GEO

The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates [ATAC-Seq]

2023-05-05 | GSE208066 | GEO

The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates [MINT ChIP-Seq]

2023-05-05 | GSE208069 | GEO

The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates

Project description:The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates

| PRJNA858094 | ENA

The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates [CUT&RUN]

Project description:The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates [CUT&RUN]

| PRJNA858098 | ENA

The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates [RNA-Seq]

Project description:The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates [RNA-Seq]

| PRJNA858097 | ENA

The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates [ATAC-Seq]

Project description:The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates [ATAC-Seq]

| PRJNA858100 | ENA

The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates [MINT ChIP-Seq]

Project description:The pioneer factor SOX9 competes for epigenetic factors to switch stem cell fates [MINT ChIP-Seq]

| PRJNA858099 | ENA

Epigenetic switch involved in activation of pioneer factor FOXA1-dependent enhancers.

Project description:Transcription factors (TFs) bind specifically to discrete regions of mammalian genomes called cis-regulatory elements. Among those are enhancers, which play key roles in regulation of gene expression during development and differentiation. Despite the recognized central regulatory role exerted by chromatin in control of TF functions, much remains to be learned regarding the chromatin structure of enhancers and how it is established. Here, we have analyzed on a genomic-scale enhancers that recruit FOXA1, a pioneer transcription factor that triggers transcriptional competency of these cis-regulatory sites. Importantly, we found that FOXA1 binds to genomic regions showing local DNA hypomethylation and that its cell-type-specific recruitment to chromatin is linked to differential DNA methylation levels of its binding sites. Using neural differentiation as a model, we showed that induction of FOXA1 expression and its subsequent recruitment to enhancers is associated with DNA demethylation. Concomitantly, histone H3 lysine 4 methylation is induced at these enhancers. These epigenetic changes may both stabilize FOXA1 binding and allow for subsequent recruitment of transcriptional regulatory effectors. Interestingly, when cloned into reporter constructs, FOXA1-dependent enhancers were able to recapitulate their cell type specificity. However, their activities were inhibited by DNA methylation. Hence, these enhancers are intrinsic cell-type-specific regulatory regions of which activities have to be potentiated by FOXA1 through induction of an epigenetic switch that includes notably DNA demethylation.

| S-EPMC3065703 | biostudies-literature

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