Transcriptomics

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Gene expression data from precision cut lung slices (PCLS) of old and young mice infected with two strains of Pseudomonas aeruginosa


ABSTRACT: The study aimed to mimic inflamm-aging using ex vivo precision-cut lung slices (PCLS) from young and old mice, and to investigate the influence of aging on inflammation upon infection with the P. aeruginosa standard lab strain PAO1 and a clinical P. aeruginosa isolate, D61. Genome-wide transcriptome analysis revealed that genes associated with processes of immune system were strongly regulated with aging upon P. aeruginosa infection. Very early events of pulmonary inflamm-aging can be mimicked ex vivo in tissue slices of distal lungs and aging promotes pulmonary inflammation upon P. aeruginosa infection

ORGANISM(S): Mus musculus

PROVIDER: GSE208375 | GEO | 2024/01/05

REPOSITORIES: GEO

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