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RNA-sequencing analysis to identify genes regulated by MYCN, WDR5 and G9a in neuroblastoma cell line IMR32

ABSTRACT: In this study we identified genes regulated by MYCN, WDR5 and G9a in IMR32 cells

ORGANISM(S): Homo sapiens

PROVIDER: GSE208420 | GEO | 2023/10/19

REPOSITORIES: GEO

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RNA-sequencing analysis to identify genes regulated by MYCN, WDR5 and G9a in neuroblastoma cell line IMR32

Project description:RNA-sequencing analysis to identify genes regulated by MYCN, WDR5 and G9a in neuroblastoma cell line IMR32

| PRJNA859872 | ENA

The cooperation between MYCN and its cofactors WDR5 and G9a on gene transcription regulation [siWDR5]

Project description:MYCN cooperates with WDR5 to activate canonical MYC targets and cooperates with G9a to repress neuronal differentiation genes.

2023-10-19 | GSE208419 | GEO

The cooperation between MYCN and its cofactors WDR5 and G9a on gene transcription regulation [siG9a]

Project description:MYCN cooperates with WDR5 to activate canonical MYC targets and cooperates with G9a to repress neuronal differentiation genes.

2023-10-19 | GSE208417 | GEO

The cooperation between MYCN and its cofactors WDR5 and G9a on gene transcription regulation [siMYCN]

Project description:MYCN cooperates with WDR5 to activate canonical MYC targets and cooperates with G9a to repress neuronal differentiation genes.

2023-10-19 | GSE208414 | GEO

The cooperation between MYCN and its cofactors WDR5 and G9a

Project description:The cooperation between MYCN and its cofactors WDR5 and G9a

| PRJNA859859 | ENA

RNA-sequencing analysis to investigate genes regulated by HAND2 and MYCN in IMR32 cells

Project description:In this study we identified genes regulated by HAND2 or MYCN or both MYCN and HAND2 in IMR32 cells.

2023-03-29 | GSE183609 | GEO

The cooperation between MYCN and its cofactors WDR5 and G9a on gene transcription regulation [siMYCN]

Project description:The cooperation between MYCN and its cofactors WDR5 and G9a on gene transcription regulation [siMYCN]

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The cooperation between MYCN and its cofactors WDR5 and G9a on gene transcription regulation [siWDR5]

Project description:The cooperation between MYCN and its cofactors WDR5 and G9a on gene transcription regulation [siWDR5]

| PRJNA859873 | ENA

The cooperation between MYCN and its cofactors WDR5 and G9a on gene transcription regulation [siG9a]

Project description:The cooperation between MYCN and its cofactors WDR5 and G9a on gene transcription regulation [siG9a]

| PRJNA859874 | ENA

Dickkopf-1 is down-regulated by MYCN and inhibits neuroblastoma cell proliferation

Project description:Neuroblastomas are tumors of the developing peripheral sympathetic nervous system, which originates from the neural crest. Twenty percent of neuroblastomas show amplification of the MYCN oncogene, which correlates with poor prognosis. The MYCN transcription factor can activate and repress gene expression. To broaden our insight in the spectrum of genes down-regulated by MYCN, we generated gene expression profiles of the neuroblastoma cell lines SHEP-21N and SKNAS-NmycER, in which MYCN activity can be regulated. In this study, we show that MYCN suppresses the expression of Dickkopf-1 (DKK1) in both cell lines. DKK1 is a potent inhibitor of the wnt/beta-catenin signalling cascade, which is known to function in neural crest cell migration. We generated a DKK1 inducible cell line, IMR32-DKK1, which showed impaired proliferation upon DKK1 expression. Surprisingly, DKK1 expression did not inhibit the canonical wnt/beta-catenin signalling, suggesting a role of DKK1 in an alternative route of the wnt pathway. Gene expression profiling of two IMR32-DKK1 clones showed that only a few genes, amongst which SYNPO2, were up-regulated by DKK1. SYNPO2 encodes an actin-binding protein and was previously found to inhibit proliferation and invasiveness of prostate cancer cells. These results suggest that MYCN might stimulate cell proliferation by inhibiting the expression of DKK1. DKK1 might exert part of its growth suppressive effect by induction of SYNPO2 expression. Keywords: DKK1, MYCN, neuroblastoma, Dickkopf

2007-08-24 | GSE8066 | GEO

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