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Interferon Regulatory Factor 5 represses mitochondrial matrix protein GHITM to limit macrophage oxidative capacity in early response to obesity [atm]

ABSTRACT: To investigate the involvement of IRF5 in macrophages during obesity-related inflammation, we analyzed adipose-tissue macrophages (ATM) from mice with a myeloid-specific deletion of IRF5 or their wild-type littermates, fed with high fat diet.

ORGANISM(S): Mus musculus

PROVIDER: GSE208648 | GEO | 2022/07/25

REPOSITORIES: GEO

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Interferon Regulatory Factor 5 represses mitochondrial matrix protein GHITM to limit macrophage oxidative capacity in early response to obesity [bmdm]

Project description:To investigate the involvement of IRF5 in macrophages during obesity-related inflammation, we analyzed bone marrow-derived macrophages stimulated for 2 or 24 hours with Lipopolysaccharide (LPS), Palmitate or carrier (bovine serum albumin), from mice with a myeloid-specific deletion of IRF5 or their wild-type littermates.

2022-07-25 | GSE208667 | GEO

Interferon Regulatory Factor 5 represses mitochondrial matrix protein GHITM to limit macrophage oxidative capacity in early response to obesity [atm]

Project description:Interferon Regulatory Factor 5 represses mitochondrial matrix protein GHITM to limit macrophage oxidative capacity in early response to obesity [atm]

| PRJNA860546 | ENA

Modulation of proteostasis counteracts oxidative stress and affects DNA base excision repair capacity in ATM-deficient cells

Project description:Ataxia telangiectasia (A-T) is a syndrome associated with loss of ATM protein function. Neurodegeneration and cancer predisposition, both hallmarks of A-T, are likely to emerge as a consequence of the persistent oxidative stress and DNA damage observed in this disease. Surprisingly however, despite these severe features, a lack of functional ATM is still compatible with early life, suggesting that adaptation mechanisms contributing to cell survival must be in place. Here we address this gap in our knowledge by analysing the process of human fibroblast adaptation to the lack of ATM. We identify profound rearrangement in cellular proteostasis occurring very early on after loss of ATM in order to counter protein damage originating from oxidative stress. Change in proteostasis, however, is not without repercussions. Modulating protein turnover in ATM-depleted cells also has an adverse effect on the DNA base excision repair pathway, the major DNA repair system that deals with oxidative DNA damage. As a consequence, the burden of unrepaired endogenous DNA lesions intensifies, progressively leading to genomic instability. Our study provides a glimpse at the cellular consequences of loss of ATM and highlights a previously overlooked role for proteostasis in maintaining cell survival in the absence of ATM function.

2017-09-04 | PXD006648 | Pride

Atm

Project description:Rattus norvegicus Atm, ATM serine/threonine kinase [Source:RGD Symbol;Acc:1593265], is differentially expressed in 25 experiment(s);

| ENSRNOG00000029773 | ExpressionAtlas

Atm

Project description:Rattus norvegicus Atm, ATM serine/threonine kinase [Source:RGD Symbol;Acc:1593265], is expressed in 5 baseline experiment(s);

| ENSRNOG00000029773 | ExpressionAtlas

ATM

Project description:Macaca mulatta ATM, ATM serine/threonine kinase [Source:VGNC Symbol;Acc:VGNC:70173], is expressed in 3 baseline experiment(s);

| ENSMMUG00000004153 | ExpressionAtlas

ATM

Project description:Oryctolagus cuniculus ATM, ATM serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:795], is expressed in 1 baseline experiment(s);

| ENSOCUG00000014663 | ExpressionAtlas

ATM

Project description:Homo sapiens ATM, ATM serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:795], is expressed in 51 baseline experiment(s);

| ENSG00000149311 | ExpressionAtlas

atm

Project description:Xenopus tropicalis atm, ATM serine/threonine kinase [Source:Xenbase;Acc:XB-GENE-493810], is expressed in 1 baseline experiment(s);

| ENSXETG00000014471 | ExpressionAtlas

ATM

Project description:Homo sapiens ATM, ATM serine/threonine kinase [Source:HGNC Symbol;Acc:HGNC:795], is differentially expressed in 182 experiment(s);

| ENSG00000149311 | ExpressionAtlas

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