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Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy

ABSTRACT: DNA methylation progiling of circulaing cell-free DNA isolatated from serum of 12 MTLE patients and 11 healthy controls. The Illumina Infinium MethylationEPIC Beadchip was used to obtain DNA methylation profiles across approximately 850,000 CpGs.

ORGANISM(S): Homo sapiens

PROVIDER: GSE208758 | GEO | 2023/01/11

REPOSITORIES: GEO

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Epilepsy progression mediates cumulative DNA methylation changes in inflammatory genes.

Project description:DNA methylation profiling of hippocampus and anterior temporal neocortex from MTLE-HS patients subjected to resective epileptic surgery and cadaveric non-epileptic controls. The Illumina Infinium MethylationEPIC Beadchip was used to obtain DNA methylation profiles across approximately 850,000 CpGs in brain homogenates.

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Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy

Project description:Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy

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Circulating cell-free DNA methylation mirrors alterations in cerebral patterns in epilepsy.

Project description:BackgroundDNA methylation profiling of circulating cell-free DNA (cfDNA) has rapidly become a promising strategy for biomarker identification and development. The cell-type-specific nature of DNA methylation patterns and the direct relationship between cfDNA and apoptosis can potentially be used non-invasively to predict local alterations. In addition, direct detection of altered DNA methylation patterns performs well as a biomarker. In a previous study, we demonstrated marked DNA methylation alterations in brain tissue from patients with mesial temporal lobe epilepsy with hippocampal sclerosis (MTLE-HS).ResultsWe performed DNA methylation profiling in cfDNA isolated from the serum of MTLE patients and healthy controls using BeadChip arrays followed by systematic bioinformatic analysis including deconvolution analysis and integration with DNase accessibility data sets. Differential cfDNA methylation analysis showed an overrepresentation of gene ontology terms and transcription factors related to central nervous system function and regulation. Deconvolution analysis of the DNA methylation data sets ruled out the possibility that the observed differences were due to changes in the proportional contribution of cortical neurons in cfDNA. Moreover, we found no overrepresentation of neuron- or glia-specific patterns in the described cfDNA methylation patterns. However, the MTLE-HS cfDNA methylation patterns featured a significant overrepresentation of the epileptic DNA methylation alterations previously observed in the hippocampus.ConclusionsOur results support the use of cfDNA methylation profiling as a rational approach to seeking non-invasive and reproducible epilepsy biomarkers.

| S-EPMC9795776 | biostudies-literature

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