Transcriptomics

Dataset Information

0

Effective Targeting of Quiescent Chronic Myelogenous Leukemia Stem Cells by Histone Deacetylase Inhibitors in Combination with Imatinib Mesylate


ABSTRACT: We investigated the ability of HDAC inhibitors (HDACi) to target CML stem cells. Treatment with HDACi combined with IM effectively induced apoptosis in quiescent CML progenitors resistant to elimination by IM alone, and eliminated CML stem cells capable of engrafting immunodeficient mice. In vivo administration of HDACi with IM markedly diminished LSC in a transgenic mouse model of CML. The interaction of IM and HDACi inhibited genes regulating hematopoietic stem cell maintenance and survival. HDACi treatment represents a novel and effective strategy to target LSC in CML patients receiving tyrosine kinase inhibitors.

ORGANISM(S): Homo sapiens

PROVIDER: GSE20876 | GEO | 2010/05/20

SECONDARY ACCESSION(S): PRJNA124671

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2010-06-08 | E-GEOD-20876 | biostudies-arrayexpress
2022-11-29 | GSE180496 | GEO
2014-06-03 | GSE48294 | GEO
2009-12-19 | GSE19567 | GEO
2016-06-01 | E-GEOD-76123 | biostudies-arrayexpress
2014-06-03 | E-GEOD-48294 | biostudies-arrayexpress
2016-03-31 | GSE75391 | GEO
2016-03-31 | GSE75389 | GEO
2011-03-15 | GSE23946 | GEO
2013-01-01 | E-GEOD-43225 | biostudies-arrayexpress