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Genome-wide maps of chromatin accessibility in DN3 thymocytes and splenic naïve CD4 T cells.

ABSTRACT: We found that naïve T cells from SCD1-/- mice have an intrinsic preference for regulatory T cells differentiation. Such preference was imprinted to DN3 thymocytes developed in SCD1 deficient thymus and persisted to mature T cells. To investigate the potential epigenetic changes underlying the Treg-bias. We employed ATAC-seq to examine the chromatin accessibility of naïve T cells and DN3 thymocytes from SCD1-/- mice and their littermate controls.

ORGANISM(S): Mus musculus

PROVIDER: GSE209563 | GEO | 2023/09/23

REPOSITORIES: GEO

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