Transcriptomics

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Tofacitinib blocks interferon-regulated biomarker genes in dermal and adventitial skin fibroblasts in early systemic sclerosis


ABSTRACT: Systemic sclerosis (SSc) is an autoimmune, connective tissue disease characterized by vasculopathy and fibrosis of the skin and internal organs. Trends in efficacy outcome measures favored tofacitnib. Baseline gene expression in fibroblast and keratinocyte subpopulations indicates interferon (IFN) activated gene expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE209635 | GEO | 2022/07/26

REPOSITORIES: GEO

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