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Whole transcriptome analysis of prostatic urethra of rats after thulium laser prostatectomy [miRNA]

ABSTRACT: To investigate the repair mechanism of urethral wound after prostatectomy, we used microarray RNA sequences and bioinformatics methods to analyze the entire transcriptome of post-urethral resection trauma tissue in the rat prostate.

ORGANISM(S): Rattus norvegicus

PROVIDER: GSE209829 | GEO | 2024/07/10

REPOSITORIES: GEO

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Whole transcriptome analysis of prostatic urethra of rats after thulium laser prostatectomy [mRNA, lncRNA, circRNA]

Project description:To investigate the repair mechanism of urethral wound after prostatectomy, we used microarray RNA sequences and bioinformatics methods to analyze the entire transcriptome of post-urethral resection trauma tissue in the rat prostate.

2024-07-10 | GSE209827 | GEO

Whole transcriptome analysis of prostatic urethra of rats after thulium laser prostatectomy

Project description:Whole transcriptome analysis of prostatic urethra of rats after thulium laser prostatectomy

| PRJNA862541 | ENA

Whole transcriptome analysis of prostatic urethra of rats after thulium laser prostatectomy

Project description:This SuperSeries is composed of the SubSeries listed below.

2024-07-10 | GSE209831 | GEO

Whole transcriptome analysis of prostatic urethra of rats after thulium laser prostatectomy [miRNA]

Project description:Whole transcriptome analysis of prostatic urethra of rats after thulium laser prostatectomy [miRNA]

| PRJNA862543 | ENA

Whole transcriptome analysis of prostatic urethra of rats after thulium laser prostatectomy [mRNA, lncRNA, circRNA]

Project description:Whole transcriptome analysis of prostatic urethra of rats after thulium laser prostatectomy [mRNA, lncRNA, circRNA]

| PRJNA862544 | ENA

Exploring Relevant mRNAs and miRNAs in Injured Urethral Tissues of Rats with High-Throughput Sequencing [RNA-seq]

Project description:Acute urethral injuries caused by urethral endoscopy and other mechanical injuries are the main reasons for secondary infection and late urethral stricture. However, there are no studies to explore the transcriptomic changes in urethral injury and the molecular mechanism of urethral injury, which is important for the treatment and cure of urethral injury. Therefore, we used RNA-seq and sRNA-seq profiles from normal and injured urethral tissues to identify and characterize differentially expressed mRNAs and miRNAs. In total, we found 166 differentially expressed mRNAs, of which 69 were upregulated, and 97 were downregulated in injured urethral tissues. The differentially expressed mRNAs were mainly involved in the positive regulation of epithelial cell differentiation, focal adhesion, cell adhesion molecules, protein activation cascade, complement activation, complement and coagulation cascades, and chemokine-mediated signaling pathway. Additionally, we found six upregulated and four downregulated miRNAs, respectively, in the injured urethral tissues. Notably, their target genes were involved in the vascular endothelial growth factor receptor 2 binding, PI3k-Akt signaling pathway, and Notch signaling pathway. In summary, our results suggest that the cell damage response induced by mechanical injury activates the pathological immune response in a variety of ways in injured urethral tissues.

2022-05-31 | GSE182642 | GEO

Exploring Relevant mRNAs and miRNAs in Injured Urethral Tissues of Rats with High-Throughput Sequencing [miRNA-seq]

2022-05-31 | GSE182947 | GEO

Laparoscopic implantation of an artificial urinary sphincter around the prostatic urethra.

Project description:ObjectiveTo report the first laparoscopic periprostatic implantation of an artificial urinary sphincter (AUS) after a transurethral resection of the prostate.BackgroundThe implantation of an AUS is a standard procedure for severe urinary incontinence. In men it is usually implanted through a perineal approach, with the cuff placed around the bulbous urethra, bladder neck, or even around the prostate.MethodWe report a laparoscopic periprostatic implantation of an AUS after a transurethral resection of a prostate in a 72-year-old-man with incontinence.ResultsThe operative duration was 180 min and the blood loss was 150 mL. There were no complications. After activating the AUS the patient was totally continent.ConclusionThe laparoscopic periprostatic implantation of an AUS is a safe, effective and considerably less invasive procedure.

| S-EPMC4563016 | biostudies-literature

Protein-coding and MicroRNA Biomarkers of Recurrence of Prostate Cancer Following Radical Prostatectomy

Project description:This SuperSeries is composed of the following subset Series: GSE26022: [Gene Expression Training Set] Protein-coding and MicroRNA Biomarkers of Recurrence of Prostate Cancer Following Radical Prostatectomy GSE26242: [Gene Expression Validation Set] Protein-coding and MicroRNA Biomarkers of Recurrence of Prostate Cancer Following Radical Prostatectomy GSE26245: [miRNA Training Set] Protein-coding and MicroRNA Biomarkers of Recurrence of Prostate Cancer Following Radical Prostatectomy GSE26247: [miRNA Validation Set] Protein-coding and MicroRNA Biomarkers of Recurrence of Prostate Cancer Following Radical Prostatectomy Refer to individual Series

2011-06-01 | E-GEOD-26367 | biostudies-arrayexpress

A Novel miRNA-Based Predictive Model for Biochemical Failure Following Post-Prostatectomy Salvage Radiation Therapy

Project description:Radical prostatectomy remains one of the more widely-used treatment options for men with prostate cancer. However, few molecular biomarkers have been established to predict patients who are at high risk of biochemical failure. To our knowledge, this is the first such report on miRNA profiling in radical prostatectomy tissue using Nanostring. In addition, this is the first report to look at the prognostic value of miRNAs in the setting of biochemical failure and salvage radiation therapy post-radical prostatectomy.

2015-01-23 | GSE65061 | GEO

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