Project description:PRTG+ve cells show high self renewability in Group 3 medulloblastoma tumors. To access the proteins differentially expressed in this subset of cells, we sorted PRTG+ve and PRTG-ve cells by surface staining with Anti-PRTG antibody from Gr3 medulloblastoma xenografts.
Project description:Total RNA sequencing was performed to understand the transcriptome alterations in Gr3-medulloblastoma lines induced by the indirect interactions of endothelial cells.
Project description:PRTG+ve cells show high self renewability in Group 3 medulloblastoma tumors and depletion of these cells reduce tumor burden in vivo. To study the functions, we silenced PRTG expression in Gr3 lines
