AMPK directly regulate a subset of genes expression in ALL cells
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ABSTRACT: To identify genome-wide genes regulated by direct association of AMPK to chromatin in response to energy/metabolic stress, we constructed CCRF-CEM (T-ALL) stable cell lines expressing HA-AMPKα2 and performed ChIP-seq and RNA-seq assays in control or glucose deprivation conditions. ChIP-seq and RNA-seq analysis identified the histone genes as a subset of genes regulated by AMPK with direct AMPKα2 occupancy at their TSS region.
ORGANISM(S): Homo sapiens
PROVIDER: GSE210214 | GEO | 2023/12/06
REPOSITORIES: GEO
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