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Methylation data from stored peripheral blood leukocytes from African American participants in the GENOA study

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE210256 | GEO | 2022/08/04

REPOSITORIES: GEO

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Methylation data from stored peripheral blood leukocytes from African American participants in the GENOA study

Project description:African-American individuals of the GENOA cohort

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Methylation data from stored peripheral blood leukocytes from African American participants in the GENOA study with Infinium HumanMethylation450 BeadChip

Project description:African-American individuals of the GENOA study

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Methylation data from stored peripheral blood leukocytes from African American participants in the GENOA study with Infinium HumanMethylationEPIC BeadChip

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Methylation data from stored peripheral blood leukocytes from African American participants in the GENOA study

Project description:Methylation data from stored peripheral blood leukocytes from African American participants in the GENOA study

| PRJNA660240 | ENA

Methylation data from stored peripheral blood leukocytes from African American participants in the GENOA study

Project description:Methylation data from stored peripheral blood leukocytes from African American participants in the GENOA study

| PRJNA864860 | ENA

Methylation data from stored peripheral blood leukocytes from African American participants in the GENOA study with Infinium HumanMethylation450 BeadChip

Project description:Methylation data from stored peripheral blood leukocytes from African American participants in the GENOA study with Infinium HumanMethylation450 BeadChip

| PRJNA864862 | ENA

Methylation data from stored peripheral blood leukocytes from African American participants in the GENOA study with Infinium HumanMethylationEPIC BeadChip

Project description:Methylation data from stored peripheral blood leukocytes from African American participants in the GENOA study with Infinium HumanMethylationEPIC BeadChip

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Gene expression data from lymphoblastoid cell lines from African American participants in the GENOA study

Project description:African-American individuals of the GENOA cohort

2019-10-17 | GSE138914 | GEO

Project description:Despite evidence linking obesity to impaired immune function, little is known about the specific mechanisms. Because of emerging evidence that immune responses are epigenetically regulated, we hypothesized that DNA methylation changes are involved in obesity induced immune dysfunction and aimed to identify these changes.We conducted a genome wide methylation analysis on seven obese cases and seven lean controls aged 14 to 18 years from extreme ends of the obesity distribution and performed further validation of six CpG sites from six genes in 46 obese cases and 46 lean controls aged 14 to 30 years.In comparison with the lean controls, we observed one CpG site in the UBASH3A gene showing higher methylation levels and one CpG site in the TRIM3 gene showing lower methylation levels in the obese cases in both the genome wide step (P = 5 × 10(-6) and P = 2 × 10(-5) for the UBASH3A and the TRIM3 gene respectively) and the validation step (P = 0.008 and P = 0.001 for the UBASH3A and the TRIM3 gene respectively).Our results provide evidence that obesity is associated with methylation changes in blood leukocyte DNA. Further studies are warranted to determine the causal direction of this relationship as well as whether such methylation changes can lead to immune dysfunction.

| S-EPMC3016263 | biostudies-literature

The effect of smoking on DNA methylation of peripheral blood mononuclear cells from African American women.

Project description:Regular smoking is associated with a wide variety of syndromes with prominent inflammatory components such as cancer, obesity and type 2 diabetes. Heavy regular smoking is also associated with changes in the DNA methylation of peripheral mononuclear cells. However, in younger smokers, inflammatory epigenetic findings are largely absent which suggests the inflammatory response(s) to smoking may be dose dependent. To help understand whether peripheral mononuclear cells have a role in mediating these responses in older smokers with higher cumulative smoke exposure, we examined genome-wide DNA methylation in a group of well characterized adult African American subjects informative for smoking, as well as serum C-reactive protein (CRP) and interleukin-6 receptor (IL6R) levels. In addition, complementary bioinformatic analyses were conducted to delineate possible pathways affected by long-term smoking.Genome-wide DNA methylation analysis with respect to smoking status yielded 910 significant loci after Benjamini-Hochberg correction. In particular, two loci from the AHRR gene (cg05575921 and cg23576855) and one locus from the GPR15 gene (cg19859270) were identified as highly significantly differentially methylated between smokers and non-smokers. The bioinformatic analyses showed that long-term chronic smoking is associated with altered promoter DNA methylation of genes coding for proteins mapping to critical sub-networks moderating inflammation, immune function, and coagulation.We conclude that chronic regular smoking is associated with changes in peripheral mononuclear cell methylation signature which perturb inflammatory and immune function pathways and may contribute to increased vulnerability for complex illnesses with inflammatory components.

| S-EPMC3936875 | biostudies-literature

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