Transcriptomics

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HAND1 knockdown disrupts trophoblast gene expression in vitro- human vascular endothelial cell


ABSTRACT: Congenital heart disease (CHD) affects nearly 1% of births annually, and neonatal and perinatal outcomes in cases of CHD are strongly impacted by pregnancy outcomes. CHD pregnancies carry increased risk of developing pathologies of abnormal placentation including fetal growth restriction, preeclampsia, preterm birth, and stillbirth. HAND1 is a gene associated with CHD. In this study, we aimed characterize the mechanistic impacts of disrupting HAND1 on human vascular endothelial cell gene expression.

ORGANISM(S): Homo sapiens

PROVIDER: GSE210318 | GEO | 2022/08/03

REPOSITORIES: GEO

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