Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

Mapping the heterogeneity of pDCs and Monocytes of systemic sclerosis at single cell level

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Homo sapiens

PROVIDER: GSE210396 | GEO | 2024/08/10

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

Mapping the heterogeneity of pDCs and Monocytes of systemic sclerosis at single cell level [scRNA-seq]

Project description:Systemic sclerosis (SSc) is an uncommon disease characterized by elevated autoantibody production, vasculopathy and fibrosis of the skin and internal organs. pDCs are the core cell type to produce type I IFN and contributes to the ISG signature and SSc progression. Using single-cell RNA sequencing, we profiled 32529 pDCs enriched and T cell depleted peripheral blood mononuclear cells (PBMCs) from 4 patients with SSc and 4 matched controls. Increased CD16+ monocytes and decreased cDCs are the major changes in the cell composition between SSc and heathy controls. Increased expression of interferon-stimulated genes (ISGs) and apoptotic genes distinguished cells from patients with SSc from healthy control cells. The high ISG expression signature (ISGhi) derived from a small number of transcriptionally defined subpopulations within major cell types, including monocytes, natural killer cells, conventional and plasmacytoid dendritic cells, B cells. Profiling of 10976 pDCs revealed a newly identified PTGDS+ population and a clear increased ISG hi clusters in SSc pDCs. Profiling of 13317 Monocytes revealed increased CD16+ Monocytes and a clear increased ISG hi clusters in SSc monocytes. We then compared the TLRs-IFN response of the pDCs from SSc and Healthy control. RNASeq revealed SSc pDCs enables an unexpected TLR8-IFN signaling to increase the IFN signature. This study lays the groundwork for resolving the origin of the SSc transcriptional signatures and the disease heterogeneity towards precision medicine applications.

2024-08-10 | GSE210395 | GEO

Mapping the heterogeneity of pDCs and Monocytes of systemic sclerosis at single cell level [Bulk RNA-seq]

2024-08-10 | GSE210394 | GEO

Mapping the heterogeneity of pDCs and Monocytes of systemic sclerosis at single cell level

Project description:Mapping the heterogeneity of pDCs and Monocytes of systemic sclerosis at single cell level

| PRJNA865561 | ENA

Mapping the heterogeneity of pDCs and Monocytes of systemic sclerosis at single cell level [scRNA-seq]

Project description:Mapping the heterogeneity of pDCs and Monocytes of systemic sclerosis at single cell level [scRNA-seq]

| PRJNA865564 | ENA

Mapping the heterogeneity of pDCs and Monocytes of systemic sclerosis at single cell level [Bulk RNA-seq]

Project description:Mapping the heterogeneity of pDCs and Monocytes of systemic sclerosis at single cell level [Bulk RNA-seq]

| PRJNA865563 | ENA

Mapping systemic lupus erythematosus heterogeneity at the single-cell level.

Project description:Patients with systemic lupus erythematosus (SLE) display a complex blood transcriptome whose cellular origin is poorly resolved. Using single-cell RNA sequencing, we profiled ~276,000 peripheral blood mononuclear cells from 33 children with SLE with different degrees of disease activity and 11 matched controls. Increased expression of interferon-stimulated genes (ISGs) distinguished cells from children with SLE from healthy control cells. The high ISG expression signature (ISGhi) derived from a small number of transcriptionally defined subpopulations within major cell types, including monocytes, CD4+ and CD8+ T cells, natural killer cells, conventional and plasmacytoid dendritic cells, B cells and especially plasma cells. Expansion of unique subpopulations enriched in ISGs and/or in monogenic lupus-associated genes classified patients with the highest disease activity. Profiling of ~82,000 single peripheral blood mononuclear cells from adults with SLE confirmed the expansion of similar subpopulations in patients with the highest disease activity. This study lays the groundwork for resolving the origin of the SLE transcriptional signatures and the disease heterogeneity towards precision medicine applications.

| S-EPMC7442743 | biostudies-literature

Classical Monocytes from African American Patients with Systemic Sclerosis

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-02-07 | GSE196071 | GEO

Multi-tissue functional genomic study of systemic sclerosis

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-01-12 | E-GEOD-76809 | biostudies-arrayexpress

CEACAM 1, 3, 5 and 6 -positive classical monocytes correlate with interstitial lung disease in early systemic sclerosis

Project description:This SuperSeries is composed of the SubSeries listed below.

2022-08-28 | GSE207425 | GEO

Multi-tissue functional genomic study of systemic sclerosis

Project description:This SuperSeries is composed of the SubSeries listed below.