Browse
Submit Data
Databases
API
Help

Dataset Information

0 Views

0 Connections

0 Citations

0 Reanalyses

0 Downloads

Omics score: 0

ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (E18.5 femur and tibia)

ABSTRACT: We used single cell RNA sequencing (scRNA-seq) to identify femur and tibia osteoblast cell stress response pathway to misfolding of type I procollagen with Gly610->Cys substitution in the triple helical region of alpha2(I) chain.

ORGANISM(S): Mus musculus

PROVIDER: GSE210511 | GEO | 2022/08/07

REPOSITORIES: GEO

ACCESS DATA

Json Xml

Dataset's files

Source:

			Action	DRS
		Other

Items per page:

1 - 1 of 1

Similar Datasets

ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (proximal tibia srRNASeq)

Project description:We used spatially resolved RNA sequencing (srRNA-seq) to identify trabecular osteoblast cell stress response pathway to misfolding of type I procollagen with Gly610->Cys substitution in the triple helical region of alpha2(I) chain (trabecular region of proximal tibia adjacent to the growth plate).

2022-08-08 | GSE210637 | GEO

ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (P5 parietal bone)

Project description:We used single cell RNA sequencing (scRNA-seq) to identify parietal osteoblast cell stress response pathway to misfolding of type I procollagen with Gly610->Cys substitution in the triple helical region of alpha2(I) chain.

2022-08-07 | GSE210519 | GEO

ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (primary cells)

Project description:We used bulk RNA sequencing (bulk RNAseq) in primary osteoblast cultures to validate scRNASeq and srRNASeq findings on osteoblast cell stress response pathway to misfolding of type I procollagen with Gly610->Cys substitution in the triple helical region of alpha2(I) chain.

2022-08-12 | GSE210796 | GEO

ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (E18.5 femur and tibia)

Project description:ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (E18.5 femur and tibia)

| PRJNA865929 | ENA

ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (proximal tibia srRNASeq)

Project description:ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (proximal tibia srRNASeq)

| PRJNA866524 | ENA

ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (primary cells)

Project description:ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (primary cells)

| PRJNA867561 | ENA

ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (P5 parietal bone)

Project description:ER, mitochondria and ISR regulation by mt-HSP70 and ATF5 upon procollagen misfolding (P5 parietal bone)

| PRJNA866080 | ENA

Redox control of the cAMP/PKA pathway during protein misfolding stress

Project description:Protein aggregation is the abnormal association of misfolded proteins into larger, often insoluble structures that can be toxic during ageing and in protein aggregation-associated diseases. This RNA-seq study in Saccharomyces cerevisiae investigated the role of Tsa1, which is a member of the highly conserved 2-Cys peroxiredoxin (Prx) enzyme family, on protein aggregation.

2021-04-19 | E-MTAB-9355 | biostudies-arrayexpress

Chicken ceca, blood, tibia, and femur

Project description:Chicken ceca, blood, tibia, and femur Raw sequence reads

| PRJNA486024 | ENA

Bone morphology in 46 BXD recombinant inbred strains and femur-tibia correlation.

Project description:We examined the bone properties of BXD recombinant inbred (RI) mice by analyzing femur and tibia and compared their phenotypes of different compartments. 46 BXD RI mouse strains were analyzed including progenitor C57BL/6J (n = 16) and DBA/2J (n = 15) and two first filial generations (D2B6F1 and B6D2F1). Strain differences were observed in bone quality and structural properties (P < 0.05) in each bone profile (whole bone, cortical bone, or trabecular bone). It is well known that skeletal phenotypes are largely affected by genetic determinants and genders, such as bone mineral density (BMD). While genetics and gender appear expectedly as the major determinants of bone mass and structure, significant correlations were also observed between femur and tibia. More importantly, positive and negative femur-tibia associations indicated that genetic makeup had an influence on skeletal integrity. We conclude that (a) femur-tibia association in bone morphological properties significantly varies from strain to strain, which may be caused by genetic differences among strains, and (b) strainwise variations were seen in bone mass, bone morphology, and bone microarchitecture along with bone structural property.

| S-EPMC4355808 | biostudies-literature

OmicsDI is part of the ELIXIR infrastructure

OmicsDI is an Elixir interoperability service. Learn more ›

Tweets

OmicsDI Databases

PRIDE
PeptideAtlas
MassIVE
JPOST Repository
Physiome Model Repository

EGA
EVA
ENA
LINCS
PAXDB
Cell Collective

MetaboLights
Metabolomics Workbench
MetabolomeExpress
GNPS
BioModels
FAIRDOMHub

ArrayExpress
dbGaP
ExpressionAtlas
GEO
NODE

Information

Databases
Help
API
Contact us
Code on GitHub
Terms of use
Submit Data