Stepwise Generation of Human Induced Pluripotent Stem Cell-Derived Cardiac Pericytes to Model Coronary Microvascular Dysfunction
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ABSTRACT: Cardiac pericytes (PC), a major mural cell type maintaining homeostasis, integrity, and perfusion of the coronary microvasculature. Here, we report a stepwise, developmental trajectory-matched approach to generate first-of-its-kind cardiac PCs from human induced pluripotent stem cells (iPSCs), which were shown to transcriptionally and functionally resemble their primary counterparts.
ORGANISM(S): Homo sapiens
PROVIDER: GSE210652 | GEO | 2022/10/17
REPOSITORIES: GEO
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