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Tumor-specific cicrRNAs elicit anti-tumor immune response via encoding cryptic peptides

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus Homo sapiens

PROVIDER: GSE210793 | GEO | 2023/10/08

REPOSITORIES: GEO

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Tumor-specific circRNAs elicit anti-tumor immune response via encoding cryptic peptides [Ribo-Seq]

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Tumor-specific circRNAs elicit anti-tumor immune response via encoding cryptic peptides [hDC RNA-seq]

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Tumor-specific circRNAs elicit anti-tumor immune response via encoding cryptic antigenic peptides

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Tumor-specific circRNAs elicit anti-tumor immune response via encoding cryptic peptides [circRNA-seq of mouse]

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Melittin-lipid nanoparticles target to lymph nodes and elicit a systemic anti-tumor immune response.

Project description:Targeted delivery of a nanovaccine loaded with a tumor antigen and adjuvant to the lymph nodes (LNs) is an attractive approach for improving cancer immunotherapy outcomes. However, the application of this technique is restricted by the paucity of suitable tumor-associated antigens (TAAs) and the sophisticated technology required to identify tumor neoantigens. Here, we demonstrate that a self-assembling melittin-lipid nanoparticle (?-melittin-NP) that is not loaded with extra tumor antigens promotes whole tumor antigen release in situ and results in the activation of antigen-presenting cells (APCs) in LNs. Compared with free melittin, ?-melittin-NPs markedly enhance LN accumulation and activation of APCs, leading to a 3.6-fold increase in antigen-specific CD8+ T cell responses. Furthermore, in a bilateral flank B16F10 tumor model, primary and distant tumor growth are significantly inhibited by ?-melittin-NPs, with an inhibition rate of 95% and 92%, respectively. Thus, ?-melittin-NPs induce a systemic anti-tumor response serving as an effective LN-targeted whole-cell nanovaccine.

| S-EPMC7048802 | biostudies-literature

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