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T cell differentiation, lineage commitment and plasticity in cancer: a multi-dimensional approach from the molecular mechanism to the patients

ABSTRACT: Cancer immunotherapy (including by checkpoint inhibitors) aims to “re-program” cells of the immune system, and most importantly CD8+ T lymphocytes, but also CD4+ T helper and regulatory cells, to reject tumors. Understanding this re-programing is both a major fundamental and translational research goal, relevant to the fundamental mechanisms of fate decision / lineage commitment, and to immunotherapy and vaccination in general. Differentiation is driven by gene expression programs that are themselves controlled epigenetically.

ORGANISM(S): Homo sapiens

PROVIDER: GSE210997 | GEO | 2022/08/14

REPOSITORIES: GEO

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