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Transcriptome data of MHCII-high and MHCII-low hematopoietic stem cells of mice

ABSTRACT: This SuperSeries is composed of the SubSeries listed below.

ORGANISM(S): Mus musculus

PROVIDER: GSE211207 | GEO | 2023/08/08

REPOSITORIES: GEO

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Transcriptome data of MHCII-high and MHCII-low hematopoietic stem cells of middle-aged mice

Project description:Analysis of MHCII-high (MHCII-hi) and MHCII-low (MHCII-lo) hematopoietic stem cells (Lineage-Sca-1+c-Kit+CD150+Flt3-CD48-). The two population of hematopoietic stem cell (HSC) were purified from the bone marrow of 12 months old (12 mo) mice. Results provide insight into the role of MHCII in HSC.

2023-08-08 | GSE211206 | GEO

Transcriptome data of MHCII-high and MHCII-low hematopoietic stem cells of mice under homeostasis

Project description:Analysis of MHCII-high (MHCII-hi) and MHCII-low (MHCII-lo) hematopoietic stem cells (Lineage-Sca-1+c-Kit+CD150+Flt3-CD48-). The two population of hematopoietic stem cell (HSC) were purified from the bone marrow of 5 months old WT mice (Ctrl). Results provide insight into the role of MHCII in HSC.

2023-08-08 | GSE211203 | GEO

Transcriptome data of MHCII-high and MHCII-low hematopoietic stem cells of mice exposed to irradiation

Project description:Analysis of MHCII-high (MHCII-hi) and MHCII-low (MHCII-lo) hematopoietic stem cells (Lineage-Sca-1+c-Kit+CD150+Flt3-CD48-). The two population of hematopoietic stem cell (HSC) were purified from the bone marrow of mice at 3 months post 5 Gy total body irradiation (IR). Results provide insight into the role of MHCII in HSC.

2023-08-08 | GSE211205 | GEO

Transcriptome data of MHCII-high and MHCII-low hematopoietic stem cells of mice

Project description:Transcriptome data of MHCII-high and MHCII-low hematopoietic stem cells of mice

| PRJNA869547 | ENA

Transcriptome data of MHCII-high and MHCII-low hematopoietic stem cells of middle-aged mice

Project description:Transcriptome data of MHCII-high and MHCII-low hematopoietic stem cells of middle-aged mice

| PRJNA869550 | ENA

Transcriptome data of MHCII-high and MHCII-low hematopoietic stem cells of mice under homeostasis

Project description:Transcriptome data of MHCII-high and MHCII-low hematopoietic stem cells of mice under homeostasis

| PRJNA869552 | ENA

Transcriptome data of MHCII-high and MHCII-low hematopoietic stem cells of mice exposed to irradiation

Project description:Transcriptome data of MHCII-high and MHCII-low hematopoietic stem cells of mice exposed to irradiation

| PRJNA869551 | ENA

Immediate and long-term effects of low doses of Î³-irradiation on hematopoietic stem cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2016-02-26 | E-GEOD-66376 | biostudies-arrayexpress

Expression data of human fetal liver hematopoietic stem and progenitors cells

Project description:This SuperSeries is composed of the SubSeries listed below. Refer to individual Series

2015-01-23 | E-GEOD-54316 | biostudies-arrayexpress

Hematopoietic stem/progenitor cell proliferation and differentiation is differentially regulated by high-density and low-density lipoproteins in mice.

Project description:RationaleHematopoietic stem/progenitor cells (HSPC) are responsible for maintaining the blood system as a result of their self-renewal and multilineage differentiation capacity. Recently, studies have suggested that HDL cholesterol may inhibit and impaired cholesterol efflux may increase HSPC proliferation and differentiation.ObjectivesWe hypothesized that LDL may enhance HSPC proliferation and differentiation while HDL might have the opposing effect which might influence the size of the pool of inflammatory cells.Methods and resultsHSPC number and function were studied in hypercholesterolemic LDL receptor knockout (LDLr(-/-)) mice on high fat diet. Hypercholesterolemia was associated with increased frequency of HSPC, monocytes and granulocytes in the peripheral blood (PB). In addition, an increased proportion of BM HSPC was in G(2)M of the cell cycle, and the percentage of HSPC and granulocyte-macrophage progenitors (GMP) increased in BM of LDLr(-/-) mice. When BM Lin-Sca-1+cKit+ (i.e. "LSK") cells were cultured in the presence of LDL in vitro we also found enhanced differentiation towards monocytes and granulocytes. Furthermore, LDL promoted lineage negative (Lin-) cells motility. The modulation by LDL on HSPC differentiation into granulocytes and motility was inhibited by inhibiting ERK phosphorylation. By contrast, when mice were infused with human apoA-I (the major apolipoprotein of HDL) or reconstituted HDL (rHDL), the frequency and proliferation of HSPC was reduced in BM in vivo. HDL also reversed the LDL-induced monocyte and granulocyte differentiation in vitro.ConclusionOur data suggest that LDL and HDL have opposing effects on HSPC proliferation and differentiation. It will be of interest to determine if breakdown of HSPC homeostasis by hypercholesterolemia contributes to inflammation and atherosclerosis progression.

| S-EPMC3492382 | biostudies-literature

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