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Alterations in oligodendrocyte transcriptional networks reveal region-specific vulnerabilities to neurological disease

ABSTRACT: We identified region-specific co-expression networks representing distinct molecular pathways in oligodendrocytes associated with human neurological disease. Bioinformatic analyses reveal molecular regulators of these networks and, in this data, we confirmed modulation of network expression in vitro in a human cell line. This work supports identification of targetable region-specific vulnerabilities to neurological disease mediated by oligodendrocytes.

ORGANISM(S): Homo sapiens

PROVIDER: GSE211281 | GEO | 2023/03/01

REPOSITORIES: GEO

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Alterations in oligodendrocyte transcriptional networks reveal region-specific vulnerabilities to neurological disease

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