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Microglia aging advances through intermediate states that drive inflammatory activation and cognitive decline

ABSTRACT: TGFB-signaling is important for the establishment of microglia homeostasis; however, it's role in aging has remained vague. We found that Tgfb1 and TGFB signaling is altered during hippocampal microglia aging. To investigate the effects that microglia-derived Tgfb1 has on microglia aging, we performed scRNA-Seq on Cd11b+ cells from the hippocampus of mature mice where Tgfb1 had been ablated from Cx3cr1 cells post-maturity.

ORGANISM(S): Mus musculus

PROVIDER: GSE211340 | GEO | 2024/07/04

REPOSITORIES: GEO

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