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Hippo signaling instructs ectopic but not normal organ growth [Liver YapTazKO+CCl4]

ABSTRACT: We conditionally deleted Yap/Taz from hepatocytes prior to induction of acute injury by injection of liver toxin carbon tetrachloride (CCl4).

ORGANISM(S): Mus musculus

PROVIDER: GSE211460 | GEO | 2022/11/19

REPOSITORIES: GEO

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Hippo signaling instructs ectopic but not normal organ growth [Liver YapTazKO+CCl4]

Project description:Hippo signaling instructs ectopic but not normal organ growth [Liver YapTazKO+CCl4]

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Hippo signaling instructs ectopic but not normal organ growth [Liver YapHyper]

Project description:We conditionally activated Yap in hepatocytes of adult mice by two different methods: we deleted the Lats1/2 kinases via injecting AAV8-Cre into Lats1/2 double floxed mice (Lats1/2 KO) and we overexpressed YAP via doxycycline feeding of mice that expressed the tetracycline-activated transactivator (rtTA) under the hepatocyte-specific ApoE promoter and human YAP from a rtTA-responsive TetO promoter (Apo>YAP).

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Hippo signaling instructs ectopic but not normal organ growth

Project description:This SuperSeries is composed of the SubSeries listed below.

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Hippo signaling instructs ectopic but not normal organ growth [Drosophila YkiHyper]

Project description:In order to study how ectopic Yki drives tissue overgrowth in Drosophila imaginal discs, we overexpressed the constitutively active Yki3SA and deleted wts in clones of cells in the entire eye-antennal imaginal disc, as well as specifically in eye disc proper cells using Optix-Gal4. Using the MARCM system allowed us to compare the effects of Yki3SA overexpression in wild-type and sd mutant clones.

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Hippo signaling instructs ectopic but not normal organ growth [Drosophila NonPupatingLarvae]

Project description:We fed wildtype larvae a special diet that lacks precursor molecules necessary for the synthesis of the molting hormone ecdysone required for pupation, thus keeping animals in the larval stage. Importantly, in these larvae, the imaginal discs grow until their terminal size is reached but they do not proceed with differentiation as this requires a pulse of ecdysone. This method thus allowed us to directly compare actively growing discs with discs at the same developmental stage that terminated proliferation after reaching their proper size.

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MicroRNA expression profiling of CCl4-induced liver fibrosis in Mus musculus

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Gene expression profile of liver tissue from carbon tetrachloride (CCl4)-treated mouse cultured ex vivo

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Hippo signaling instructs ectopic but not normal organ growth

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