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Identifying signatures of EV secretion in metastatic breast cancer through functional single-cell profiling

ABSTRACT: Extracellular vesicles (EVs) regulate the tumor microenvironment by facilitating transport of biomolecular cargo including RNA, protein, and metabolites. We developed an integrated method to identify individual cells with differences in EV secretion and linked single-cell RNA-sequencing on cloned single cells from MDAMB231 cell line. Additionally, We profiled parental MDAMB231, MCF7 and HCC70 cell lines.

ORGANISM(S): Homo sapiens

PROVIDER: GSE211561 | GEO | 2023/03/27

REPOSITORIES: GEO

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Growth media conditions influence the secretion route and release levels of engineered extracellular vesicles

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