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Synovial fibroblasts assume distinct functional identities and secrete R‑spondin 2 to drive osteoarthritis

ABSTRACT: Synovium is acutely affected following joint trauma and contributes to post-traumatic osteoarthritis (PTOA) progression. Little is known about discrete cell types and molecular mechanisms in PTOA synovium. We aimed to describe synovial cell populations and their dynamics in PTOA. Single-cell RNA-seq profiling of synovium revealed fibroblasts (comprised of various functional subsets), macrophages, endothelial cells and pericytes to be the predominanent synovial cell types, along with rarer populations including T cells, Schwann cells and mast cells. Cell types undergo profound changes in abundance and gene expression following joint injury.

ORGANISM(S): Mus musculus

PROVIDER: GSE211584 | GEO | 2022/08/25

REPOSITORIES: GEO

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A normative study of the synovial fluid proteome from healthy porcine knee joints

Project description:Synovial fluid in an articulating joint contains proteins derived from blood transudates, and proteins that are produced by cells within joint tissues, such as synovium, cartilage, ligament, and meniscus. The proteome composition of healthy synovial fluid is not fully understood. Also not fully delineated are the cellular origins of synovial fluid components. We here present a normative proteomics study for synovial fluid optimized in pig.

2014-09-09 | PXD000935 | Pride

Synovial fibroblasts assume distinct functional identities and secrete R-spondin 2 in osteoarthritis.

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