Transcriptomics

Dataset Information

0

The genomic and immune landscape of long-term survivors of high-grade serous ovarian cancer [RNAseq]


ABSTRACT: Less than half of all patients with advanced-stage high-grade serous ovarian cancers (HGSC) survive more than five years post-diagnosis but those who have an exceptionally long survival could provide new insights into tumor biology and therapeutic approaches. We analyzed 60 patients with advanced-stage, HGSC who survived more than 10 years after diagnosis using whole-genome sequencing, transcriptome, and methylome profiling of their primary tumor samples, comparing this data to 66 short- or moderate-term survivors. Tumors of long-term survivors were more likely to have multiple alterations in genes associated with DNA repair, and more frequent somatic variants resulting in an increased predicted neoantigen load. Patients clustered into survival groups based on genomic and immune cell signatures, including three subsets of patients with BRCA1 alterations with distinctly different outcomes. Specific combinations of germline and somatic gene alterations, tumor cell phenotypes, and differential immune responses appear to contribute to long-term survival in HGSC.

ORGANISM(S): Homo sapiens

PROVIDER: GSE211669 | GEO | 2022/08/26

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2022-08-26 | GSE211686 | GEO
| EGAS00001005984 | EGA
2016-02-11 | E-GEOD-44272 | biostudies-arrayexpress
2014-03-27 | E-GEOD-53733 | biostudies-arrayexpress
2016-02-11 | GSE44272 | GEO
2011-10-31 | GSE33331 | GEO
2011-10-31 | E-GEOD-33331 | biostudies-arrayexpress
2014-03-27 | GSE53733 | GEO
2010-05-16 | E-GEOD-16444 | biostudies-arrayexpress
2023-12-11 | GSE249282 | GEO