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Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes (miRNA-Seq)

ABSTRACT: Compare miRNA expression between the sexes in normal mouse brain development at embryonic day 15.5 (E15.5).

ORGANISM(S): Mus musculus

PROVIDER: GSE211815 | GEO | 2023/02/02

REPOSITORIES: GEO

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Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes (RNA-Seq)

Project description:Compare miRNA expression between the sexes in normal mouse brain development at embryonic day 15.5 (E15.5).

2023-02-02 | GSE211814 | GEO

Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes.

Project description:BackgroundSex differences pose a challenge and an opportunity in biomedical research. Understanding how sex chromosomes and hormones affect disease-causing mechanisms will shed light on the mechanisms underlying predominantly idiopathic sex-biased neurodevelopmental disorders such as ADHD, schizophrenia, and autism. Gene expression is a crucial conduit for the influence of sex on developmental processes; therefore, this study focused on sex differences in gene expression and the regulation of gene expression. The increasing interest in microRNAs (miRNAs), small, non-coding RNAs, for their contribution to normal and pathological neurodevelopment prompted us to test how miRNA expression differs between the sexes in the developing brain.MethodsHigh-throughput sequencing approaches were used to identify transcripts, including miRNAs, that showed significantly different expression between male and female brains on day 15.5 of development (E15.5).ResultsRobust sex differences were identified for some genes and miRNAs, confirming the influence of biological sex on RNA. Many miRNAs that exhibit the greatest differences between males and females have established roles in neurodevelopment, implying that sex-biased expression may drive sex differences in developmental processes. In addition to highlighting sex differences for individual miRNAs, gene ontology analysis suggested several broad categories in which sex-biased RNAs might act to establish sex differences in the embryonic mouse brain. Finally, mining publicly available SNP data indicated that some sex-biased miRNAs reside near the genomic regions associated with neurodevelopmental disorders.ConclusionsTogether, these findings reinforce the importance of cataloguing sex differences in molecular biology research and highlight genes, miRNAs, and pathways of interest that may be important for sexual differentiation in the mouse and possibly the human brain.

| S-EPMC10486049 | biostudies-literature

Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes

Project description:This SuperSeries is composed of the SubSeries listed below.

2023-02-02 | GSE211816 | GEO

Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes

Project description:Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes

| PRJNA872166 | ENA

Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes (miRNA-Seq)

Project description:Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes (miRNA-Seq)

| PRJNA872169 | ENA

Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes (RNA-Seq)

Project description:Sex-biased gene and microRNA expression in the developing mouse brain is associated with neurodevelopmental functions and neurological phenotypes (RNA-Seq)

| PRJNA872170 | ENA

Sex-biased expression in Drosophila willistoni

Project description:We performed mRNA sequencing of samples isolated from the heads, thoraxes, and abdomens of males and females of Drosophila willistoni to identify genes that are differentially expressed between the sexes. Comparison of expression levels in females and males

2012-04-08 | E-GEOD-31723 | biostudies-arrayexpress

Sex-biased expression in Drosophila willistoni

2012-04-08 | GSE31723 | GEO

Sex-biased expression profile of Schistosoma mansoni microRNAs

2013-07-31 | GSE49359 | GEO

Sex-biased expression profile of Schistosoma mansoni microRNAs

Project description:Schistosoma mansoni is a dioecious species, that is, it has two differentiated sexes. Interestingly, this sexual species evolved from a hermaphrodite ancestor. Indeed, most Platyhelminthes are hermaphrodites. Here we characterize the microRNAs of S. mansoni and quantify their differential expression between males and females. Mice were infected with Schistosoma mansoni 1-2 weeks prior to dissection. RNA from two independent samples were extracted and sequenced with Illumina MiSeq technology and AB SOLiD 4 technology. Reads were mapped to the reference genome and microRNA detected and analyzed.

2013-07-31 | E-GEOD-49359 | biostudies-arrayexpress

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