Effect of iron depletion on gene expression of NCOA4-deficient and control HT22 hippocampal neuron cells
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ABSTRACT: To determine the physiological roles of NCOA4 and NCOA4-mediated ferritinophagy in hippocampal neurons, NCOA4 was depleted using siRNA and desferrioxamine (DFO; 100 µM, 24 h) was added to restrict iron availability. Cells were treated for NCOA4 depletion, iron restriction, or both, and then the transcriptome profiles acquired from RNA-seq were compared with those of control (scramble siRNA-treated) cells.
ORGANISM(S): Mus musculus
PROVIDER: GSE211931 | GEO | 2022/12/30
REPOSITORIES: GEO
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