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Epigenetic regulation of profibrotic macrophages in systemic sclerosis- associated interstitial lung disease

ABSTRACT: Systemic sclerosis-associated interstitial lung disease (SSc-ILD) is the leading cause of death in patients with systemic sclerosis (SSc) with unclear pathogenesis and limited treatment options. Evidence strongly supports an important role for profibrotic, SPP1-expressing macrophages in SSc-ILD. We sought to define the transcriptome and chromatin structural changes of SPP1 SSc-ILD macrophages, so as to better understand their role in promoting fibrosis and to identify transcription factors associated with open chromatin driving their altered phenotype.

ORGANISM(S): Homo sapiens

PROVIDER: GSE212109 | GEO | 2022/09/02

REPOSITORIES: GEO

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