Transcriptomics

Dataset Information

0

18F-fluorodeoxy-glucose positron emission tomography marks MYC-overexpressing human basal-like breast cancers.


ABSTRACT: Fluorine-18-fluoro-2-deoxy-D-glucose (FDG) is widely used as positron-emission-tomography (PET) radiotracer for the detection and staging of human cancer. Tumor uptake of FDG varies substantially between different cancer types and between patients with the same tumor type. The molecular basis for this heterogeneity is unknown. Using cancer cell lines and primary human tumors of distinct histologic origins, we here show that increased FDG uptake is universally associated with coordinate upregulation of genes within the glycolysis, pentose-phosphate, and other related metabolic pathways. In primary human breast cancers, this FDG signature shows significant overlap with established breast cancer signatures for the “basal-like” disease subtype and “poor prognosis”. FDG high breast cancer showed significantly more gene copy number alterations genome wide than FDG low cancers. About 50 % of primary breast cancers with high FDG uptake and FDG gene expression signature show DNA copy gain encompassing the c-myc gene locus and express gene sets regulated by the transcription factor MYC. Our data shows that FDG-PET marks a distinct subset of “basal-like” human breast cancer which is characterized by MYC and prognostically unfavorable gene expression signatures, suggesting that FDG-PET imaging may be useful to risk-stratify patients with locally advanced breast cancer.

ORGANISM(S): Homo sapiens

PROVIDER: GSE21217 | GEO | 2011/11/01

SECONDARY ACCESSION(S): PRJNA126315

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2011-11-01 | E-GEOD-21217 | biostudies-arrayexpress
2020-03-18 | GSE135565 | GEO
2020-03-18 | GSE131769 | GEO
2018-06-06 | GSE99790 | GEO
2022-04-05 | GSE164961 | GEO
2012-12-01 | E-MEXP-3730 | biostudies-arrayexpress
2022-11-29 | GSE218758 | GEO
2015-04-14 | E-GEOD-54323 | biostudies-arrayexpress
2023-12-21 | GSE192464 | GEO
2021-09-08 | GSE150934 | GEO