Methylation profiling

Dataset Information

0

Towards the DNA methylation haplotype map of 11 common solid cancers


ABSTRACT: Aberrant DNA methylation is an epigenetic hallmark of cancer, known to play an essential role in cancer initiation, progression and drug resistance. Traditional analyses focus on mean methylation that measures the aggregated signal across a group of cells and neglect intra-sample heterogeneity. Sequencing-based techniques such as whole genome bisulfite sequencing (WGBS) are now widely used to measure DNA methylation on each read at single-nucleotide resolution. A single read fragment stems from a single chromosome of a single cell and represents a DNA methylation haplotype (mHap). In this study, we have profiled 110 fresh frozen tumor samples that cover 11 most common solid cancer types using WGBS and constructed a comprehensive DNA methylation haplotype map.

ORGANISM(S): Homo sapiens

PROVIDER: GSE212391 | GEO | 2024/08/23

REPOSITORIES: GEO

Dataset's files

Source:
Action DRS
Other
Items per page:
1 - 1 of 1

Similar Datasets

2014-06-01 | E-GEOD-53740 | biostudies-arrayexpress
2023-08-02 | GSE239605 | GEO
2004-02-29 | GSE590 | GEO
2013-04-01 | E-GEOD-45149 | biostudies-arrayexpress
2017-02-19 | GSE79215 | GEO
2017-02-19 | GSE79211 | GEO
2017-02-19 | GSE79277 | GEO
2023-12-18 | GSE250451 | GEO
2016-02-01 | E-GEOD-65726 | biostudies-arrayexpress
2014-06-01 | GSE53740 | GEO