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Differential gene expression between DLD-1 cells lines with moderately and significantly upregulated levels of Snail

ABSTRACT: Using human colon cancer DLD-1 cells, we engineered a cell line with a doxycycline-inducible single-copy of Snail and compared it to an existing EMT models in DLD-1 where Snail was introduced by episome transfection. Induction of the single-copy line (Snail-lo) with doxycycline increased Snail expression to a level similar to that observed in cancer cell lines spontaneously expressing Snail and results in partial EMT. In comparison, higher levels of overexpression arising from introduction of episomal-Snail (Snail-hi), results in complete EMT.

ORGANISM(S): Homo sapiens

PROVIDER: GSE212490 | GEO | 2022/09/03

REPOSITORIES: GEO

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Differential gene expression between DLD-1 cells lines with moderately and significantly upregulated levels of Snail

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