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Hypermitotic meningiomas harbor DNA methylation subgroups with distinct biological and clinical features

ABSTRACT: This study reports clinical, genetic, epigenetic, gene expression, and cellular features distinguishing meningioma DNA methylation subgroups within meningioma DNA methylation groups. We present these data in the context of molecular and clinical models predicting postoperative outcomes across 565 meningiomas with comprehensive clinical follow-up from independent discovery and validation institutions. By discovering meningioma DNA methylation subgroups within meningioma DNA methylation groups, we provide an opportunity to resolve inconsistencies in the recent literature. In doing so, our study establishes an architecture that unifies opposing biological theories for the most common primary intracranial tumor

ORGANISM(S): Homo sapiens

PROVIDER: GSE212666 | GEO | 2022/10/10

REPOSITORIES: GEO

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