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The effect of extreme hyperglycemia on the expression program of the human beta cell line EndoC-betaH2

ABSTRACT: Our in vivo Insulin-rtTA;TET-DTA mouse model of severe hyperglycemia revealed that proloned exposure to very high glucose levels inhibits cell cycle entry and progression of pancreatic beta cells. To investigate the molecular mechanisms responsible for this observation and the relevance to human beta cells, we performed an in vitro experiment on EndoC-betaH2 mimiking the in vivo conditions and subjected them to RNAseq analysis.

ORGANISM(S): Homo sapiens

PROVIDER: GSE212749 | GEO | 2022/12/01

REPOSITORIES: GEO

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