Transcriptomics

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Transcriptome analysis of MET-constitutively active versus MET-silenced colorectal cancer cells


ABSTRACT: To investigate the expression patterns driven by hyperactivated MET in MET-dependent cells, we employed LoVo colon adenocarcinoma cell line, harbouring a post-translational modification of MET that leads to its constitutive activation. We then silenced MET in LoVo cells using CRISPR/Cas9 knock-out (KO) protocol, and performed gene expression profiling analysis using data obtained from RNA-seq of cells with hyperactivated-MET versus MET-KO.

ORGANISM(S): Homo sapiens

PROVIDER: GSE212835 | GEO | 2023/10/14

REPOSITORIES: GEO

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