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Mechanisms of Restoring T Cell Immunity after Cure of Chronic Viral Infection

ABSTRACT: Understanding the molecular mechanisms of T cell exhaustion and reinvigoration is crucial to improving T cell based immunotherapy. In this study we confirmed key differences between memory and exhausted antigen-specific CD8+ T cells in hepatitis C virus infection before and after antiviral treatment. After viral cure, we observed the although phenotypically they seem to recover, functionally they showed little improvement and critical transcriptional regulators remained in exhausted state.

ORGANISM(S): Homo sapiens

PROVIDER: GSE212871 | GEO | 2022/09/08

REPOSITORIES: GEO

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